Abstract
Alzheimer's disease, a neurodegenerative illness, has the extremely complex pathogenesis. Accumulating evidence indicates there is a close relationship between several enzymes and Alzheimer's disease. Various substituted 3-arylcoumarin derivatives were synthesised, and their in vitro activity, including cholinesterase inhibitory activity, monoamine oxidase inhibitory activity, and antioxidant activity were investigated. Most of the compounds exhibited high activity; therefore 3-arylcoumarin compounds have the potential as drug candidates for the treatment of Alzheimer's disease.
Keywords:
3-Arylcoumarin; Alzheimer’s disease; antioxidant activity; cholinesterase inhibitors; monoamine oxidase inhibitors.
MeSH terms
-
Acetylcholinesterase / metabolism*
-
Alzheimer Disease / drug therapy*
-
Alzheimer Disease / metabolism
-
Animals
-
Antioxidants / chemical synthesis
-
Antioxidants / chemistry
-
Antioxidants / pharmacology*
-
Cholinesterase Inhibitors / chemical synthesis
-
Cholinesterase Inhibitors / chemistry
-
Cholinesterase Inhibitors / pharmacology*
-
Coumarins / chemical synthesis
-
Coumarins / chemistry
-
Coumarins / pharmacology*
-
Dose-Response Relationship, Drug
-
Molecular Structure
-
Monoamine Oxidase / metabolism*
-
Monoamine Oxidase Inhibitors / chemical synthesis
-
Monoamine Oxidase Inhibitors / chemistry
-
Monoamine Oxidase Inhibitors / pharmacology*
-
Rats, Wistar
-
Structure-Activity Relationship
-
Zebrafish
Substances
-
Antioxidants
-
Cholinesterase Inhibitors
-
Coumarins
-
Monoamine Oxidase Inhibitors
-
Monoamine Oxidase
-
Acetylcholinesterase
Grants and funding
The authors are grateful to support from the Science and Technology Research Programme of Shandong Academy of Medical Sciences (2017–16), Shandong Provincial Natural Science Foundation [ZR2018LH021] and the Innovation Project of Shandong Academy of Medical Sciences.