Remission and Progression-Free Survival in Patients With Newly Diagnosed Multiple Myeloma Treated With Carfilzomib, Lenalidomide, and Dexamethasone: Five-Year Follow-up of a Phase 2 Clinical Trial

JAMA Oncol. 2018 Dec 1;4(12):1781-1783. doi: 10.1001/jamaoncol.2018.5457.

Abstract

This 5-year follow-up of a phase 2 clinical trial assesses long-term durability of minimal residual disease–negative remission and time to disease progression among patients with newly diagnosed multiple myeloma who received triplet-based induction therapy with lenalidomide maintenance therapy.

Publication types

  • Clinical Trial, Phase II
  • Letter

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Dexamethasone / administration & dosage*
  • Dexamethasone / adverse effects
  • Drug Resistance, Neoplasm / drug effects
  • Female
  • Follow-Up Studies
  • Humans
  • Lenalidomide / administration & dosage*
  • Lenalidomide / adverse effects
  • Male
  • Middle Aged
  • Multiple Myeloma / diagnosis
  • Multiple Myeloma / drug therapy*
  • Multiple Myeloma / pathology
  • Neoadjuvant Therapy
  • Neoplasm Recurrence, Local / drug therapy
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm, Residual
  • Oligopeptides / administration & dosage*
  • Oligopeptides / adverse effects
  • Progression-Free Survival
  • Remission Induction
  • Treatment Outcome

Substances

  • Oligopeptides
  • carfilzomib
  • Dexamethasone
  • Lenalidomide