Pre-treatment with somatostatin in the anaesthetic management of a patient with carcinoid syndrome

Can J Anaesth. 1988 Jul;35(4):413-6. doi: 10.1007/BF03010865.

Abstract

Carcinoid syndrome produces flushing, bronchoconstriction and gastrointestinal hypermotility secondary to serotonin, histamine, bradykinin and prostaglandin release. A variety of drugs, foods and anaesthetic agents may provoke this syndrome. Under anaesthesia, the flushing produced may be associated with acute hypotension and cardiovascular collapse; this phenomenon is called a carcinoid crisis. Recently, somatostatin analogue has been used successfully to treat intraoperative carcinoid crisis. In this report, we present a 66-year-old lady with carcinoid syndrome who was pre-treated with 50 micrograms somatostatin analogue IV and IM prior to surgical manipulation. The anaesthetic course was relatively uneventful and the patient did well postoperatively.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anesthesia, General*
  • Anesthesia, Inhalation
  • Anesthesia, Intravenous
  • Female
  • Humans
  • Ileal Neoplasms / surgery
  • Malignant Carcinoid Syndrome / physiopathology
  • Malignant Carcinoid Syndrome / surgery*
  • Ovarian Neoplasms / surgery
  • Premedication*
  • Somatostatin / administration & dosage
  • Somatostatin / analogs & derivatives*

Substances

  • Somatostatin