Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update

Masao Omata; Ann-Lii Cheng; Norihiro Kokudo; Masatoshi Kudo; Jeong Min Lee; Jidong Jia; Ryosuke Tateishi; Kwang-Hyub Han; Yoghesh K Chawla; Shuichiro Shiina; Wasim Jafri; Diana Alcantara Payawal; Takamasa Ohki; Sadahisa Ogasawara; Pei-Jer Chen; Cosmas Rinaldi A Lesmana; Laurentius A Lesmana; Rino A Gani; Shuntaro Obi; A Kadir Dokmeci; Shiv Kumar Sarin

doi:10.1007/s12072-017-9799-9

Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update

Hepatol Int. 2017 Jul;11(4):317-370. doi: 10.1007/s12072-017-9799-9. Epub 2017 Jun 15.

Authors

Masao Omata^{1

2}, Ann-Lii Cheng³, Norihiro Kokudo⁴, Masatoshi Kudo⁵, Jeong Min Lee⁶, Jidong Jia⁷, Ryosuke Tateishi⁸, Kwang-Hyub Han⁹, Yoghesh K Chawla¹⁰, Shuichiro Shiina¹¹, Wasim Jafri¹², Diana Alcantara Payawal¹³, Takamasa Ohki¹⁴, Sadahisa Ogasawara¹⁵, Pei-Jer Chen¹⁶, Cosmas Rinaldi A Lesmana^{17

18}, Laurentius A Lesmana¹⁷, Rino A Gani¹⁸, Shuntaro Obi¹⁹, A Kadir Dokmeci²⁰, Shiv Kumar Sarin²¹

Affiliations

¹ Department of Gastroenterology, Yamanashi Prefectural Central Hospital, Kofu-city, Yamanashi, Japan. aug8808@yahoo.co.jp.
² The University of Tokyo, Tokyo, Japan. aug8808@yahoo.co.jp.
³ Department of Oncology and Internal Medicine, National Taiwan University Hospital, National Taiwan University Cancer Center and Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan.
⁴ Hepato-Biliary-Pancreatic Surgery Division and Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
⁵ Department of Gastroenterology and Hepatology, Kindai University School of Medicine, Osaka-Sayama, Osaka, Japan.
⁶ Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
⁷ Beijing Key Laboratory of Translational Medicine on Cirrhosis, National Clinical Research Center for Digestive Diseases, Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
⁸ Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
⁹ Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
¹⁰ Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
¹¹ Department of Gastroenterology, Juntendo University, Tokyo, Japan.
¹² Department of Medicine, Aga Khan University and Hospital, Karachi, Pakistan.
¹³ Department of Hepatology, Cardinal Santos Medical Center, Manila, Philippines.
¹⁴ Department of Gastroenterology, Mitsui Memorial Hospital, Tokyo, Japan.
¹⁵ Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba, Japan.
¹⁶ Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
¹⁷ Digestive Disease and GI Oncology Center, Medistra Hospital, University of Indonesia, Jakarta, Indonesia.
¹⁸ Department of Internal Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia.
¹⁹ Third Department of Internal Medicine, Teikyo University School of Medicine, Chiba, Japan.
²⁰ Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey.
²¹ Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.

Abstract

There is great geographical variation in the distribution of hepatocellular carcinoma (HCC), with the majority of all cases worldwide found in the Asia-Pacific region, where HCC is one of the leading public health problems. Since the "Toward Revision of the Asian Pacific Association for the Study of the Liver (APASL) HCC Guidelines" meeting held at the 25th annual conference of the APASL in Tokyo, the newest guidelines for the treatment of HCC published by the APASL has been discussed. This latest guidelines recommend evidence-based management of HCC and are considered suitable for universal use in the Asia-Pacific region, which has a diversity of medical environments.

Keywords: APASL; Asia–Pacific; Hepatocellular carcinoma; Treatment algorithm.

Publication types

Review

MeSH terms

Asia
Carcinoma, Hepatocellular / epidemiology*
Carcinoma, Hepatocellular / therapy
Carcinoma, Hepatocellular / virology
Coinfection / epidemiology
Disease Management
Evidence-Based Medicine
Hepatitis B / epidemiology*
Hepatitis B / therapy
Hepatitis C / epidemiology*
Hepatitis C / therapy
Humans
Liver Neoplasms / epidemiology*
Liver Neoplasms / therapy
Liver Neoplasms / virology
Meta-Analysis as Topic
Practice Guidelines as Topic