Role of Interleukin-10 Gene Promoter Region Polymorphism in the Development of Chronic Lymphoid Leukemia

V A Ovsepyan; A Kh Gabdulkhakova; A A Shubenkiva; E N Zotina

doi:10.1007/s10517-015-3148-6

Role of Interleukin-10 Gene Promoter Region Polymorphism in the Development of Chronic Lymphoid Leukemia

Bull Exp Biol Med. 2015 Dec;160(2):275-7. doi: 10.1007/s10517-015-3148-6. Epub 2015 Dec 8.

Authors

V A Ovsepyan¹, A Kh Gabdulkhakova², A A Shubenkiva², E N Zotina²

Affiliations

¹ Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia. vovsepyan@mail.ru.
² Kirov Institute of Hematology and Blood Transfusion, Kirov, Russia.

PMID: 26642793
DOI: 10.1007/s10517-015-3148-6

Abstract

Relationship between interleukin-10 (IL-10) gene G-1082A (rs1800896) polymorphism and the risk of development and stages of chronic lymphoid leukemia is studied in ethnic Russian residents of the Kirov region of Russia. Associations of allele -1082A and genotypes (-1082AA/-1082AG) with the risk of chronic lymphoid leukemia are detected (OR=1.39, 95%CI=1.09-1.78 and OR=1.66, 95%CI=1.09-2.54, respectively). In addition, association of 1082AA genotype with late stages of the disease by the moment of diagnosis is detected. These data indicate that IL-10 polymorphism G-1082A may be involved in the pathogenesis of chronic lymphoid leukemia.

Keywords: chronic lymphoid leukemia; interleukin-10; single nucleotide polymorphism.

MeSH terms

Adult
Aged
Aged, 80 and over
Alleles
Female
Gene Frequency / genetics
Genetic Predisposition to Disease / genetics
Genotype
Humans
Interleukin-10 / genetics*
Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics*
Promoter Regions, Genetic / genetics
White People

Substances

IL10 protein, human
Interleukin-10