Molecular action mechanisms of solar infrared radiation and heat on human skin

Ageing Res Rev. 2014 Jul:16:1-11. doi: 10.1016/j.arr.2014.03.006. Epub 2014 Apr 15.

Abstract

The generation of ROS underlies all solar infrared-affected therapeutic and pathological cutaneous effects. The signaling pathway NF-kB is responsible for the induced therapeutic effects, while the AP-1 for the pathological effects. The different signaling pathways of infrared-induced ROS and infrared-induced heat shock ROS were shown to act independently multiplying the influence on each other by increasing the doses of irradiation and/or increasing the temperature. The molecular action mechanisms of solar infrared radiation and heat on human skin are summarized and discussed in detail in the present paper. The critical doses are determined. Protection strategies against infrared-induced skin damage are proposed.

Keywords: Antioxidants; Free radicals; Pathways; Safety doses; Skin aging.

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants / pharmacology
  • Hot Temperature / adverse effects*
  • Humans
  • Infrared Rays / adverse effects*
  • NF-kappa B / metabolism
  • Oxidative Stress / drug effects
  • Oxidative Stress / radiation effects*
  • Reactive Oxygen Species / metabolism*
  • Risk Assessment
  • Risk Factors
  • Signal Transduction / radiation effects
  • Skin / drug effects
  • Skin / metabolism
  • Skin / radiation effects*
  • Transcription Factor AP-1 / metabolism

Substances

  • Antioxidants
  • NF-kappa B
  • Reactive Oxygen Species
  • Transcription Factor AP-1