Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor

F Ishikawa; K Miyazono; U Hellman; H Drexler; C Wernstedt; K Hagiwara; K Usuki; F Takaku; W Risau; C H Heldin

doi:10.1038/338557a0

Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor

Nature. 1989 Apr 13;338(6216):557-62. doi: 10.1038/338557a0.

Authors

F Ishikawa¹, K Miyazono, U Hellman, H Drexler, C Wernstedt, K Hagiwara, K Usuki, F Takaku, W Risau, C H Heldin

Affiliation

¹ Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.

PMID: 2467210
DOI: 10.1038/338557a0

Abstract

Cloning and sequencing of the complementary DNA for platelet-derived endothelial cell growth factor indicates that it is a novel factor distinct from previously characterized proteins. The factor, a protein with a relative molecular mass of about 45,000, stimulates endothelial cell growth and chemotaxis in vitro and angiogenesis in vivo.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Blotting, Northern
Blotting, Southern
Chemotaxis
Chick Embryo
Cloning, Molecular
DNA
Mice
Mice, Nude
Molecular Sequence Data
Neovascularization, Pathologic*
Platelet-Derived Growth Factor / physiology*
Tumor Cells, Cultured

Substances

Platelet-Derived Growth Factor
DNA