Abstract
Forty patients with advanced squamous cell carcinoma of the esophagus were treated with a combination of cisplatin, 5-FU (by continuous 5-day infusion), and allopurinol; 37 are evaluable for response. Thirteen remissions (35%) were obtained, including three complete and ten partial, with a median duration of 9 months. After chemotherapy, seven responding patients underwent a surgical procedure, which was radical in four. The most frequent side effects were nausea and vomiting. This regimen is effective and can be included in a multimodality approach.
MeSH terms
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Adult
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Aged
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Allopurinol / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Carcinoma, Squamous Cell / drug therapy*
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Carcinoma, Squamous Cell / pathology
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Cisplatin / administration & dosage
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Combined Modality Therapy
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Drug Evaluation
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Esophageal Neoplasms / drug therapy*
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Esophageal Neoplasms / pathology
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Female
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Fluorouracil / administration & dosage
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Humans
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Male
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Middle Aged
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Neoplasm Invasiveness
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Neoplasm Recurrence, Local / drug therapy
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Palliative Care
Substances
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Allopurinol
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Cisplatin
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Fluorouracil