Abstract
Angiogenesis is a crucial process in the growth and progression of cancer, correlating with the metastatic potential of tumour cells. Angiopoietins are ligands for the endothelium-specific tyrosine kinase Tie2 receptor, which comprise 4 structurally related proteins, termed angiopoietin (Ang)-1, Ang-2, Ang-3 and Ang-4. The roles of Ang-1 and Ang-2 have recently been clarified as crucial in angiogenesis. In this report, we measured serum Ang-1 and Ang-2 levels in patients with cutaneous T-cell lymphoma (CTCL). Serum levels of Ang-2, but not Ang-1, in patients with Sézary syndrome were significantly higher than those in patch mycosis fungoides (MF), plaque/tumour MF, and healthy controls. In patients with CTCL, serum Ang-2 correlated with disease activity. Moreover, the numbers of Ang-2+ cells in lesional skin of CTCL were significantly larger than those in normal skin. These results suggest that Ang-2 may have important roles in the development of CTCL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Angiopoietin-1 / analysis
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Angiopoietin-1 / blood*
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Angiopoietin-2 / analysis
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Angiopoietin-2 / blood*
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Biomarkers, Tumor / blood*
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Case-Control Studies
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Chemokines, CC / blood
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Disease Progression
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Female
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Humans
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Immunoglobulin E / blood
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L-Lactate Dehydrogenase / blood
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Male
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Middle Aged
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Mycosis Fungoides / blood*
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Mycosis Fungoides / chemistry
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Mycosis Fungoides / pathology
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Neovascularization, Pathologic / blood
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Platelet Endothelial Cell Adhesion Molecule-1 / analysis
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Receptors, Interleukin-2 / blood
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Sezary Syndrome / blood*
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Sezary Syndrome / chemistry
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Sezary Syndrome / pathology
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Skin / blood supply
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Skin / chemistry
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Skin Neoplasms / blood supply
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Skin Neoplasms / blood*
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Skin Neoplasms / chemistry
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Skin Neoplasms / pathology
Substances
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Angiopoietin-1
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Angiopoietin-2
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Biomarkers, Tumor
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Chemokines, CC
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Platelet Endothelial Cell Adhesion Molecule-1
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Receptors, Interleukin-2
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Immunoglobulin E
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L-Lactate Dehydrogenase