Abstract
Objective:
The aim of this study was to evaluate the prognostic value of VEGF and IL-8 in pleural effusion in patients with lung cancer.
Materials and method:
Commercially available ELISA was used to determine VEGF and IL-8 levels.
Results:
The level of VEGF showed significant correlations with lymph node metastasis and distant metastasis. But, IL-8 was only correlated with lymph node metastasis. Univariate and multivariate analysis revealed elevated VEGF level was an independent predictor of shorter OS and DFS.
Conclusion:
VEGF could be an important component that contributes to pleural effusion formation, and an important prognostic factor for lung cancer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / metabolism*
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Adenocarcinoma / mortality
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Adenocarcinoma / secondary
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Adult
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Aged
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Aged, 80 and over
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Biomarkers, Tumor / metabolism
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Carcinoma, Squamous Cell / metabolism*
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Carcinoma, Squamous Cell / mortality
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Carcinoma, Squamous Cell / secondary
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Disease-Free Survival
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Female
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Humans
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Interleukin-8 / metabolism*
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Kaplan-Meier Estimate
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Lung Neoplasms / metabolism*
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Lung Neoplasms / mortality
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Lung Neoplasms / pathology
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Lymphatic Metastasis
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Male
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Middle Aged
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Multivariate Analysis
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Pleural Effusion, Malignant / metabolism*
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Pleural Effusion, Malignant / mortality
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Pleural Effusion, Malignant / pathology
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Prognosis
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Vascular Endothelial Growth Factor A / metabolism*
Substances
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Biomarkers, Tumor
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Interleukin-8
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VEGFA protein, human
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Vascular Endothelial Growth Factor A