Tumorigenesis by a long wavelength UV-A source

Photochem Photobiol. 1990 Mar;51(3):325-30. doi: 10.1111/j.1751-1097.1990.tb01718.x.

Abstract

Albino hairless mice (Skh-hr1) were exposed daily to radiation from a high-power long wavelength UV-A source (wavelengths longer than 340 nm). The irradiations lasted 2 h per day. The daily dose was 220 kJ/m2. Heavy scratching marks were observed in 13 out of 48 animals. However during the experiment 31 of the animals developed tumors of 1 mm or larger before any scratching was observed. The median induction time was 265 days for 1 mm tumors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dose-Response Relationship, Radiation
  • Female
  • Male
  • Mice
  • Mice, Hairless
  • Neoplasms, Radiation-Induced / pathology*
  • Skin Neoplasms / etiology
  • Skin Neoplasms / pathology*
  • Ultraviolet Rays*