Abstract
Development of new, targeted antibreast cancer drug which can treat both the hormone receptor (positive and negative) breast cancers is a very challenging task. The concept of molecular hybridization led us to discover a novel class of coumarin-monastrol hybrid, as a novel breast cancer agent which selectively induce apoptosis in both primary and metastatic breast cancer cell lines.
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects
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Breast Neoplasms / drug therapy*
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Breast Neoplasms / pathology
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Cell Cycle / drug effects
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Coumarins / chemistry
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Coumarins / pharmacology*
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Dose-Response Relationship, Drug
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Drug Discovery*
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Drug Screening Assays, Antitumor
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Female
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Humans
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MCF-7 Cells
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Molecular Structure
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Pyrimidines / chemistry
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Pyrimidines / pharmacology*
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Structure-Activity Relationship
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Thiones / chemistry
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Thiones / pharmacology*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Coumarins
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Pyrimidines
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Thiones
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monastrol
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coumarin