Abstract
A new strategy to exploit galectin presence to target matrix metalloproteinases (MMPs) is presented. A bifunctional conjugate with lactose and an inhibitor for MMPs is able to bind MMP and Gal-3 simultaneously. This compound might allow the lectin to attract the MMP inhibitor to the tumour site and to block protumoural activities of the lectin at the same time.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acetamides / chemical synthesis*
-
Acetamides / chemistry*
-
Acetamides / pharmacology*
-
Enzyme Inhibitors / chemistry*
-
Enzyme Inhibitors / pharmacology*
-
Galectins / chemistry*
-
Galectins / metabolism*
-
Glycoconjugates / chemistry*
-
Humans
-
Hydrophobic and Hydrophilic Interactions
-
Lectins / chemistry*
-
Ligands
-
Magnetic Resonance Spectroscopy
-
Matrix Metalloproteinase Inhibitors / chemistry*
-
Matrix Metalloproteinase Inhibitors / pharmacology*
-
Matrix Metalloproteinases / chemistry*
-
Matrix Metalloproteinases / metabolism*
-
Neoplasms
-
Sulfonamides / chemical synthesis*
-
Sulfonamides / chemistry*
-
Sulfonamides / pharmacology*
Substances
-
Acetamides
-
Enzyme Inhibitors
-
Galectins
-
Glycoconjugates
-
Lectins
-
Ligands
-
Matrix Metalloproteinase Inhibitors
-
NNGH compound
-
Sulfonamides
-
Matrix Metalloproteinases