Targeting matrix metalloproteinases: design of a bifunctional inhibitor for presentation by tumour-associated galectins

Chemistry. 2013 Feb 4;19(6):1896-902. doi: 10.1002/chem.201203794. Epub 2012 Dec 27.

Abstract

A new strategy to exploit galectin presence to target matrix metalloproteinases (MMPs) is presented. A bifunctional conjugate with lactose and an inhibitor for MMPs is able to bind MMP and Gal-3 simultaneously. This compound might allow the lectin to attract the MMP inhibitor to the tumour site and to block protumoural activities of the lectin at the same time.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / chemical synthesis*
  • Acetamides / chemistry*
  • Acetamides / pharmacology*
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology*
  • Galectins / chemistry*
  • Galectins / metabolism*
  • Glycoconjugates / chemistry*
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Lectins / chemistry*
  • Ligands
  • Magnetic Resonance Spectroscopy
  • Matrix Metalloproteinase Inhibitors / chemistry*
  • Matrix Metalloproteinase Inhibitors / pharmacology*
  • Matrix Metalloproteinases / chemistry*
  • Matrix Metalloproteinases / metabolism*
  • Neoplasms
  • Sulfonamides / chemical synthesis*
  • Sulfonamides / chemistry*
  • Sulfonamides / pharmacology*

Substances

  • Acetamides
  • Enzyme Inhibitors
  • Galectins
  • Glycoconjugates
  • Lectins
  • Ligands
  • Matrix Metalloproteinase Inhibitors
  • NNGH compound
  • Sulfonamides
  • Matrix Metalloproteinases