Expression of the potential cancer stem cell markers, CD133, CD44, ALDH1, and β-catenin, in primary lung adenocarcinoma--their prognostic significance

Pathol Int. 2012 Dec;62(12):792-801. doi: 10.1111/pin.12019.

Abstract

The present study investigated expression profiles of the potential CSC markers including CD133, CD44, ALDH1, and β-catenin, and evaluated their prognostic value in lung adenocarcinomas. One-hundred-and-seventy-seven tumors (stage I) were immunohistochemically examined for the expression of these markers, and thresholds to subdivide expression levels were determined using receiver operating characteristics curves. Tumors with high levels of CD133 (adjusted hazard ratio (HR) 4.55 (95% confidence interval (CI) 1.26-16.40, P = 0.021), CD44 (HR 3.73, 95% CI 1.20-11.58, P = 0.023) or ALDH1 (HR 3.61, 95% CI 1.09-12.3, P = 0.036), but not β-catenin (HR 2.43, 95% CI 0.59-10.8, P = 0.220), showed a significantly higher risk of recurrence than the corresponding low expressers. In conclusion, levels of CD133, CD44, and ALDH1 had independent prognostic value to predict the recurrence of lung adenocarcinoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AC133 Antigen
  • Adenocarcinoma / metabolism*
  • Adenocarcinoma / mortality
  • Adenocarcinoma / pathology
  • Aged
  • Aged, 80 and over
  • Aldehyde Dehydrogenase 1 Family
  • Antigens, CD / analysis
  • Antigens, CD / biosynthesis
  • Area Under Curve
  • Biomarkers, Tumor / analysis*
  • Female
  • Glycoproteins / analysis
  • Glycoproteins / biosynthesis
  • Humans
  • Hyaluronan Receptors / analysis
  • Hyaluronan Receptors / biosynthesis
  • Immunohistochemistry
  • Isoenzymes / analysis
  • Isoenzymes / biosynthesis
  • Kaplan-Meier Estimate
  • Lung Neoplasms / metabolism*
  • Lung Neoplasms / mortality
  • Lung Neoplasms / pathology
  • Male
  • Middle Aged
  • Neoplastic Stem Cells / metabolism*
  • Peptides / analysis
  • Proportional Hazards Models
  • ROC Curve
  • Retinal Dehydrogenase / analysis
  • Retinal Dehydrogenase / biosynthesis
  • Sensitivity and Specificity
  • beta Catenin / analysis
  • beta Catenin / biosynthesis

Substances

  • AC133 Antigen
  • Antigens, CD
  • Biomarkers, Tumor
  • Glycoproteins
  • Hyaluronan Receptors
  • Isoenzymes
  • PROM1 protein, human
  • Peptides
  • beta Catenin
  • Aldehyde Dehydrogenase 1 Family
  • ALDH1A1 protein, human
  • Retinal Dehydrogenase