Abstract
Curcumin (Hcur) as a cellular imaging and PDT agent shows remarkable photocytotoxicity in HeLa cells in visible light of 400-700 nm giving IC(50) = 8.2 ± 0.2 μM and its degradation is arrested on formation of photocytotoxic dipyridophenazine (dppz) complex [VO(cur)(dppz)Cl] (IC(50) = 3.3 ± 0.4 μM), while both are less toxic in the dark.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / chemical synthesis*
-
Antineoplastic Agents / pharmacology
-
Cell Survival / drug effects
-
Cell Survival / radiation effects
-
Coordination Complexes / chemical synthesis*
-
Coordination Complexes / pharmacology
-
Crystallography, X-Ray
-
Curcumin / chemistry*
-
DNA Cleavage / drug effects
-
DNA Cleavage / radiation effects
-
HeLa Cells
-
Humans
-
Inhibitory Concentration 50
-
Light
-
Microscopy, Confocal
-
Molecular Structure
-
Photosensitizing Agents / chemical synthesis*
-
Photosensitizing Agents / pharmacology
-
Spectrum Analysis
-
Vanadates / chemistry*
Substances
-
Antineoplastic Agents
-
Coordination Complexes
-
Photosensitizing Agents
-
oxovanadium IV
-
Vanadates
-
Curcumin