Abstract
The anaplastic lymphoma kinase (ALK) receptor tyrosine kinase is now implicated in a wide range of human cancers. Results from recent clinical trials with ALK inhibitors provide promise for patients harboring oncogenic ALK lesions. This review will discuss our current understanding of ALK in human cancer and the implication of recent results for treatment.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Anaplastic Lymphoma Kinase
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Humans
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Mutation
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Neoplasms / enzymology*
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Protein Kinase Inhibitors / pharmacology
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Receptor Protein-Tyrosine Kinases / antagonists & inhibitors
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Receptor Protein-Tyrosine Kinases / chemistry
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Receptor Protein-Tyrosine Kinases / genetics
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Receptor Protein-Tyrosine Kinases / metabolism*
Substances
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Protein Kinase Inhibitors
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ALK protein, human
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Anaplastic Lymphoma Kinase
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Receptor Protein-Tyrosine Kinases