Abstract
Two new xanthone-anthraquinone heterodimers, acremoxanthone C (5) and acremoxanthone D (2), have been isolated from an extract of an unidentified fungus of the order Hypocreales (MSX 17022) by bioactivity-directed fractionation as part of a search for anticancer leads from filamentous fungi. Two known related compounds, acremonidin A (4) and acremonidin C (3) were also isolated, as was a known benzophenone, moniliphenone (1). The structures of these isolates were determined via extensive use of spectroscopic and spectrometric tools in conjunction with comparisons to the literature. All compounds (1-5) were evaluated against a suite of biological assays, including those for cytotoxicity, inhibition of the 20S proteasome, mitochondrial transmembrane potential and nuclear factor-κB.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Anthraquinones / chemistry
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Anthraquinones / isolation & purification*
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Anthraquinones / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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Humans
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Hypocreales / chemistry*
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Membrane Potential, Mitochondrial / drug effects
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Molecular Structure
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NF-kappa B / antagonists & inhibitors
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NF-kappa B / metabolism
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Nuclear Magnetic Resonance, Biomolecular
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Optical Rotation
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Proteasome Endopeptidase Complex / metabolism
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Xanthones / chemistry
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Xanthones / isolation & purification*
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Xanthones / pharmacology*
Substances
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Anthraquinones
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Antineoplastic Agents
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NF-kappa B
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Xanthones
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Proteasome Endopeptidase Complex