Nodal/Activin signaling: a novel target for pancreatic cancer stem cell therapy

Timothy R Donahue; David W Dawson

doi:10.1016/j.stem.2011.10.006

Nodal/Activin signaling: a novel target for pancreatic cancer stem cell therapy

Cell Stem Cell. 2011 Nov 4;9(5):383-4. doi: 10.1016/j.stem.2011.10.006.

Authors

Timothy R Donahue¹, David W Dawson

Affiliation

¹ Departments of Surgery and Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA.

PMID: 22056131
DOI: 10.1016/j.stem.2011.10.006

Abstract

Targeting of cancer stem cells (CSCs) has the potential to address the recalcitrance of pancreatic cancer to chemotherapy. In this issue of Cell Stem Cell, Lonardo et al. (2011) demonstrate that Nodal/Activin signaling is crucial for the maintenance and tumor-initiating capacity of pancreatic CSCs.

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