Nidurufin as a new cell cycle inhibitor from marine-derived fungus Penicillium flavidorsum SHK1-27

Hong Ren; Wei-Wei Liu

doi:10.1007/s12272-011-0606-1

Nidurufin as a new cell cycle inhibitor from marine-derived fungus Penicillium flavidorsum SHK1-27

Arch Pharm Res. 2011 Jun;34(6):901-5. doi: 10.1007/s12272-011-0606-1. Epub 2011 Jul 2.

Authors

Hong Ren¹, Wei-Wei Liu

Affiliation

¹ Beijing Key Laboratory of Plant Resource Research and Development, Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, College of Chemical and Environmental Engineering, Beijing Technology and Business University, Beijing 100048, China. renhong@th.btbu.edu.cn

PMID: 21725810
DOI: 10.1007/s12272-011-0606-1

Abstract

A new cell cycle inhibitor, nidurufin (1), was isolated from the marine-derived fungus Penicillium flavidorsum SHK1-27. An evaluation of antitumor activity indicated that 1 induced in vitro cell cycle arrest at G(2)/M transition in the K562 cell line in a concentration and time dependent manner, with an IC(50) value of 12.6 M.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anthraquinones / administration & dosage
Anthraquinones / isolation & purification
Anthraquinones / pharmacology*
Cell Cycle / drug effects*
Cell Division / drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
G2 Phase / drug effects
Humans
Inhibitory Concentration 50
K562 Cells
Leukemia, Myeloid / drug therapy*
Leukemia, Myeloid / pathology
Penicillium / chemistry*
Time Factors

Substances

Anthraquinones
nidurufin