Abstract
Breast cancer is the most incident cancer among women. We investigated the role of polymorphisms of folate metabolizing genes MTHFR (C677T and A1298C), SHMT1 (C1420T) and MTHFD (G1258A) in genetic susceptibility to this type of cancer. We determined allele and genotype frequencies in case (850 women with sporadic form of breast cancer) and control (810 women) groups. None of these polymorphisms was significantly associated with breast cancer risk. To increase statistical power of our study, we conducted a meta-analysis which included published genotype data and the results of our work. Meta-analysis also revealed no significant association of studied SNPs with breast cancer.
MeSH terms
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Adult
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Aged
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Breast Neoplasms / enzymology
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Breast Neoplasms / epidemiology
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Breast Neoplasms / genetics*
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Female
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Folic Acid / genetics
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Folic Acid / metabolism
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Genetic Loci*
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Genetic Predisposition to Disease / epidemiology
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Genetic Predisposition to Disease / genetics
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Glycine Hydroxymethyltransferase / genetics*
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Glycine Hydroxymethyltransferase / metabolism
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Humans
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Methylenetetrahydrofolate Dehydrogenase (NADP) / genetics*
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Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
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Methylenetetrahydrofolate Reductase (NADPH2) / metabolism
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Middle Aged
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Minor Histocompatibility Antigens
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Polymorphism, Single Nucleotide*
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Siberia / epidemiology
Substances
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Minor Histocompatibility Antigens
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Folic Acid
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Methylenetetrahydrofolate Reductase (NADPH2)
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MTHFD1 protein, human
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Methylenetetrahydrofolate Dehydrogenase (NADP)
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Glycine Hydroxymethyltransferase
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SHMT protein, human