Atypical fibroxanthoma with keloidal collagen

Am J Dermatopathol. 2010 Oct;32(7):713-5. doi: 10.1097/DAD.0b013e3181c4c563.

Abstract

Atypical fibroxanthoma (AFX) is a lesion that typically occurs on actinically damaged skin of the head and neck. Histopathology of these neoplasms reveals atypical cells, which often demonstrate positive staining for immunohistochemical markers such as vimentin and CD10. In the case reported, keloidal collagen was discovered on histopathology. To our knowledge, only rare reports in the literature describe an AFX with similar histopathologic findings, suggesting that this is a distinctive presentation of AFX.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / analysis
  • Collagen Type I / biosynthesis*
  • Diabetes Mellitus
  • Ear / pathology
  • Histiocytoma, Benign Fibrous / metabolism
  • Histiocytoma, Benign Fibrous / pathology*
  • Histiocytoma, Benign Fibrous / surgery
  • Humans
  • Hypertension / complications
  • Immunohistochemistry
  • Kidney Failure, Chronic / complications
  • Male
  • Middle Aged
  • Neprilysin / biosynthesis
  • Procollagen / biosynthesis*
  • Renal Dialysis
  • Skin Neoplasms / metabolism
  • Skin Neoplasms / pathology*
  • Skin Neoplasms / surgery

Substances

  • Biomarkers, Tumor
  • Collagen Type I
  • Procollagen
  • Neprilysin