Abstract
Multidrug resistance (MDR) is the cause of an ever-increasing number of problems in the treatment of cancers and bacterial infections. The active efflux of drugs contributes significantly to this phenomenon. This minireview summarizes recent advances in combating MDR, with particular emphasis on natural and synthetic efflux pump inhibitors of P-glycoprotein in resistant tumor cells and of the NorA MDR pump in Staphylococcus aureus.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors*
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
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Bacterial Infections / drug therapy
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Bacterial Proteins / antagonists & inhibitors*
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Bacterial Proteins / metabolism
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Calcium Channel Blockers / therapeutic use
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Drug Resistance, Multiple*
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Immunosuppressive Agents / therapeutic use
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Multidrug Resistance-Associated Proteins / antagonists & inhibitors*
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Multidrug Resistance-Associated Proteins / metabolism
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Neoplasms / drug therapy
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Bacterial Proteins
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Calcium Channel Blockers
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Immunosuppressive Agents
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Multidrug Resistance-Associated Proteins
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NorA protein, Staphylococcus