Heat treatment of electrospun silicate fiber substrates enhances cellular adhesion and proliferation

Tetsu Yamaguchi; Shinji Sakai; Rie Watanabe; Takashi Tarao; Koei Kawakami

doi:10.1016/j.jbiosc.2009.08.482

Heat treatment of electrospun silicate fiber substrates enhances cellular adhesion and proliferation

J Biosci Bioeng. 2010 Mar;109(3):304-6. doi: 10.1016/j.jbiosc.2009.08.482. Epub 2009 Sep 17.

Authors

Tetsu Yamaguchi¹, Shinji Sakai, Rie Watanabe, Takashi Tarao, Koei Kawakami

Affiliation

¹ Biotechnology and Food Research Institute, Fukuoka Industrial Technology Center, 1465-5 Aikawa, Kurume, Fukuoka 839-0861, Japan. tetsu@fitc.pref.fukuoka.jp

PMID: 20159582
DOI: 10.1016/j.jbiosc.2009.08.482

Abstract

Synthetic scaffolds support cell attachment in vitro. We prepared ultra-fine silicate fibers using the sol-gel process and electrospinning, heated the fibers to 500 degrees C and investigated their effects on the behavior of human hepatocellular carcinoma (HepG2) cells. Alterations in surface composition following heat treatment improved cell adhesion and influenced cell migration.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Adhesion / physiology*
Cell Proliferation*
Electrochemistry / methods*
Hep G2 Cells
Hot Temperature
Humans
Materials Testing
Nanostructures / chemistry*
Nanostructures / ultrastructure
Rotation
Silicates / chemistry*
Tissue Engineering / methods*
Tissue Scaffolds*

Substances

Silicates