Abstract
A new study now reports recurrent somatic mutation of EZH2, a histone methyltransferase that modifies H3K27, in diffuse large B-cell lymphoma (DLBCL). There is now evidence for both increased and decreased activity of enzymes controlling H3K27 methylation in cancer, suggesting that a precise balance of this methylation is critical for normal cell growth.
MeSH terms
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / genetics
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Enhancer of Zeste Homolog 2 Protein
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Germinal Center / metabolism
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Germinal Center / pathology
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Histones / metabolism*
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Humans
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Lymphoma, Follicular / genetics*
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Lymphoma, Large B-Cell, Diffuse / genetics
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Lymphoma, Large B-Cell, Diffuse / pathology
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Lysine / metabolism*
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Methylation
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Mutation / genetics
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Polycomb Repressive Complex 2
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Transcription Factors / chemistry
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Transcription Factors / genetics
Substances
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DNA-Binding Proteins
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Histones
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Transcription Factors
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EZH2 protein, human
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Enhancer of Zeste Homolog 2 Protein
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Polycomb Repressive Complex 2
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Lysine