Smoking behavior in women with locally advanced cervical carcinoma: a Gynecologic Oncology Group study

Am J Obstet Gynecol. 2010 Mar;202(3):283.e1-7. doi: 10.1016/j.ajog.2009.10.884. Epub 2009 Dec 30.

Abstract

Objective: The purpose of this study was to assess cigarette use and environmental smoke exposure in women with cervical cancer.

Study design: Smoking behavior was recorded prospectively in a clinical trial of women with locally advanced cervical carcinoma.

Results: Of 315 participants, 133 women (42%) were current smokers; 72 women (23%) were former smokers, and 110 women (35%) were never smokers. Current smokers began smoking earlier (16 vs 18 years; P = .009), for more years (29 vs 24 years; P = .005), and in greater amounts (20 vs 11 cigarettes/d; P < .001) than former smokers. Active smokers lived more often with another smoker (63.3%), compared with former smokers (35.0%; P < .001) or never-smokers (28.7%; P < .001). Agreement between self-report and urine cotinine level was high (kappa = 0.872; P < .001). A significant decrease in cotinine level during treatment occurred in 5.2% of current smokers.

Conclusion: Prevalence of smoking and tobacco consumption was twice that of the North American female population. Few smokers quit or decreased consumption during treatment.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Carcinoma / epidemiology*
  • Carcinoma / therapy
  • Cotinine / urine
  • Female
  • Humans
  • Middle Aged
  • Prospective Studies
  • Smoking / epidemiology*
  • Tobacco Smoke Pollution / statistics & numerical data*
  • Uterine Cervical Neoplasms / epidemiology*
  • Uterine Cervical Neoplasms / therapy

Substances

  • Tobacco Smoke Pollution
  • Cotinine