This retrospective analysis examined the daily/weekly patterns of sexual activity, by age and marital status, of men with erectile dysfunction (ED) participating in a 12-week, multicenter, open-label study of tadalafil (20 mg) as needed. The timing of intercourse attempts post dose and satisfaction were assessed using the Sexual Encounter Profile diary. Patients' behaviors regarding sexual self-confidence, spontaneity and time concerns were assessed with the Psychological and Interpersonal Relationship Scale. Overall, the timing of sexual intercourse attempts varied among patients, regardless of age or marital status; at least 46% of intercourse attempts occurred within the 4-36-h post-dose time interval. Across age groups and marital status, men treated with tadalafil reported greater satisfaction compared with baseline; they also reported fewer time concerns, improved self-confidence and improved spontaneity. Information regarding sexual behavioral patterns of men with ED is important to consider when discussing patient expectations.