Abstract
Radiotherapy of head and neck malignancies results in severe damage to salivary glands. Irradiation-induced sialadenitis with xerostomia leads to a significant deterioration of the quality of life which lasts life-long. Here we show in a preliminary study that intraglandular application of botulinum toxin performed prior to radiation reduces significantly the radiation induced toxicity of the glandular tissue in rats.
MeSH terms
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Animals
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Anti-Dyskinesia Agents / therapeutic use
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Botulinum Toxins / therapeutic use*
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Disease Models, Animal
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Male
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Radiation Injuries, Experimental / prevention & control*
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Radiation-Protective Agents / therapeutic use*
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Radionuclide Imaging
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Rats
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Rats, Wistar
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Sialadenitis / prevention & control*
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Submandibular Gland / diagnostic imaging
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Submandibular Gland / radiation effects*
Substances
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Anti-Dyskinesia Agents
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Radiation-Protective Agents
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Botulinum Toxins