Objective: To investigate whether the gene polymorphisms for p21, X-ray repair cross-complementing group 1 (XRCC1), human 8-oxoguanine glycosylase 1 (hOGG1), and dopamine D1 and D2 receptors (DRD1, -2) are associated with leiomyoma susceptibility.
Design: Prospective study.
Setting: Departments of gynecology and genetics in a medical center.
Patient(s): Women were divided into two groups: leiomyoma (n = 120) and nonleiomyoma (n = 112).
Intervention(s): The p21 codon 31, XRCC1 codon 399, hOGG1 codon 326, DRD1-48, and DRD2 codon 313 polymorphisms were genotyped by polymerase chain reaction with restriction enzyme digestions (Blp I, MspI, Fnu4HI, Dde I, and NcoI, respectively).
Main outcome measure(s): Genotypes and allelic frequencies.
Result(s): The p21 codon 31(*)C- and DRD2 codon 313(*)T-related genotypes/alleles were associated with the presence of leiomyomas. The proportions of p21(*)CC/CA/AA and DRD2(*)CC/CT/TT in both groups were 27.5/68.3/4.2% and 12.5/51.7/35.8% (leiomyoma); and 14.3/51.8/33.9% and 33.9/40.2/25.9% (nonleiomyoma). XRCC1, hOGG1, and DRD1 were not correlated with the presence of leiomyomas. XRCC1(*)GG/GA/AA, hOGG1(*)TT/TA/AA, and DRD1(*)GG/GA/AA were 54.2/37.5/8.3%, 36.7/44.2/19.1%, and 3.3/25.8/70.8% (leiomyoma); and 48.2/47.3/4.5%, 43.6/41/15.4%, and 3.6/25/71.4% (nonleiomyoma).
Conclusion(s): The p21 codon 31(*)C- and DRD2 codon 313(*)T-related genotypes/alleles were associated with the presence of leiomyoma. XRCC1, hOGG1, and DRD1 were not correlated with leiomyoma development.