Human papillomavirus in HNSCC: recognition of a distinct disease type

Hematol Oncol Clin North Am. 2008 Dec;22(6):1125-42, vii. doi: 10.1016/j.hoc.2008.08.006.

Abstract

Strong epidemiologic and molecular data now support the conclusion that human papillomavirus (HPV) infection is responsible for a distinct form of head and neck squamous cell carcinoma (HNSCC), independent from the traditional risk factors of tobacco and alcohol use. Patients with HPV-positive HNSCC have a different clinical presentation and better clinical outcomes than those with HPV-negative HNSCC. A diagnosis of HPV-positive HNSCC is associated not only with therapeutic relevance, but also has important implications for future prevention and screening strategies.

Publication types

  • Review

MeSH terms

  • Adult
  • Cell Transformation, Viral / genetics
  • Female
  • Human papillomavirus 16* / genetics
  • Human papillomavirus 16* / metabolism
  • Humans
  • Male
  • Middle Aged
  • Mouth Neoplasms* / diagnosis
  • Mouth Neoplasms* / epidemiology
  • Mouth Neoplasms* / genetics
  • Mouth Neoplasms* / metabolism
  • Mouth Neoplasms* / therapy
  • Mouth Neoplasms* / virology
  • Neoplasms, Squamous Cell* / diagnosis
  • Neoplasms, Squamous Cell* / epidemiology
  • Neoplasms, Squamous Cell* / genetics
  • Neoplasms, Squamous Cell* / metabolism
  • Neoplasms, Squamous Cell* / therapy
  • Neoplasms, Squamous Cell* / virology
  • Oncogene Proteins, Viral / genetics
  • Oncogene Proteins, Viral / metabolism
  • Papillomavirus E7 Proteins
  • Papillomavirus Infections* / diagnosis
  • Papillomavirus Infections* / epidemiology
  • Papillomavirus Infections* / genetics
  • Papillomavirus Infections* / metabolism
  • Papillomavirus Infections* / therapy
  • Prognosis
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism
  • Retinoblastoma Protein / genetics
  • Retinoblastoma Protein / metabolism
  • Sexually Transmitted Diseases* / diagnosis
  • Sexually Transmitted Diseases* / epidemiology
  • Sexually Transmitted Diseases* / genetics
  • Sexually Transmitted Diseases* / metabolism
  • Sexually Transmitted Diseases* / therapy
  • Sexually Transmitted Diseases* / virology
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism
  • United States / epidemiology

Substances

  • E6 protein, Human papillomavirus type 16
  • Oncogene Proteins, Viral
  • Papillomavirus E7 Proteins
  • Repressor Proteins
  • Retinoblastoma Protein
  • TP53 protein, human
  • Tumor Suppressor Protein p53
  • oncogene protein E7, Human papillomavirus type 16