Abstract
Strong epidemiologic and molecular data now support the conclusion that human papillomavirus (HPV) infection is responsible for a distinct form of head and neck squamous cell carcinoma (HNSCC), independent from the traditional risk factors of tobacco and alcohol use. Patients with HPV-positive HNSCC have a different clinical presentation and better clinical outcomes than those with HPV-negative HNSCC. A diagnosis of HPV-positive HNSCC is associated not only with therapeutic relevance, but also has important implications for future prevention and screening strategies.
MeSH terms
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Adult
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Cell Transformation, Viral / genetics
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Female
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Human papillomavirus 16* / genetics
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Human papillomavirus 16* / metabolism
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Humans
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Male
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Middle Aged
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Mouth Neoplasms* / diagnosis
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Mouth Neoplasms* / epidemiology
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Mouth Neoplasms* / genetics
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Mouth Neoplasms* / metabolism
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Mouth Neoplasms* / therapy
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Mouth Neoplasms* / virology
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Neoplasms, Squamous Cell* / diagnosis
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Neoplasms, Squamous Cell* / epidemiology
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Neoplasms, Squamous Cell* / genetics
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Neoplasms, Squamous Cell* / metabolism
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Neoplasms, Squamous Cell* / therapy
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Neoplasms, Squamous Cell* / virology
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Oncogene Proteins, Viral / genetics
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Oncogene Proteins, Viral / metabolism
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Papillomavirus E7 Proteins
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Papillomavirus Infections* / diagnosis
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Papillomavirus Infections* / epidemiology
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Papillomavirus Infections* / genetics
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Papillomavirus Infections* / metabolism
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Papillomavirus Infections* / therapy
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Prognosis
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Repressor Proteins / genetics
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Repressor Proteins / metabolism
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Retinoblastoma Protein / genetics
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Retinoblastoma Protein / metabolism
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Sexually Transmitted Diseases* / diagnosis
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Sexually Transmitted Diseases* / epidemiology
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Sexually Transmitted Diseases* / genetics
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Sexually Transmitted Diseases* / metabolism
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Sexually Transmitted Diseases* / therapy
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Sexually Transmitted Diseases* / virology
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Tumor Suppressor Protein p53 / genetics
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Tumor Suppressor Protein p53 / metabolism
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United States / epidemiology
Substances
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E6 protein, Human papillomavirus type 16
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Oncogene Proteins, Viral
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Papillomavirus E7 Proteins
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Repressor Proteins
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Retinoblastoma Protein
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TP53 protein, human
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Tumor Suppressor Protein p53
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oncogene protein E7, Human papillomavirus type 16