Abstract
The effect of piperine, the main alkaloid from piper nigrum, on the central nervous system is not clearly known until now. In the present study, male Wistar rats were administered piperine at various doses ranging from 5, 10 and 20mg/kg BW once daily for 4 weeks and the animals were determined the neuropharmacological activity after single, 1, 2, 3 and 4 weeks of treatment. The results showed that piperine at all dosage range used in this study possessed anti-depression like activity and cognitive enhancing effect at all treatment duration. Therefore, piperine may be served as the potential functional food to improve brain function. However, further investigations about precise underlying mechanism are still required.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / pharmacology
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Alkaloids / therapeutic use*
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Animals
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Antidepressive Agents / pharmacology
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Anxiety / psychology
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Behavior, Animal / drug effects
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Benzodioxoles / pharmacology
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Benzodioxoles / therapeutic use*
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Cognition Disorders / drug therapy*
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Cognition Disorders / psychology
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Food Analysis
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Male
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Maze Learning / drug effects
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Mood Disorders / drug therapy*
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Mood Disorders / psychology
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Motor Activity / drug effects
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Piperidines / pharmacology
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Piperidines / therapeutic use*
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Polyunsaturated Alkamides / pharmacology
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Polyunsaturated Alkamides / therapeutic use*
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Rats
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Rats, Wistar
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Swimming / psychology
Substances
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Alkaloids
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Antidepressive Agents
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Benzodioxoles
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Piperidines
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Polyunsaturated Alkamides
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piperine