Abstract
A 39-year-old male underwent distal gastrectomy for a high grade gastrointestinal stromal tumor (GIST). Computed tomography (CT) and magnetic resonance imaging (MRI) 107 mo after the operation, revealed a cystic mass (14 cm in diameter) and a solid mass (9 cm in diameter) in the right and left lobes of the liver, respectively. A biopsy specimen of the solid mass showed a liver metastasis of GIST. The patient received imatinib mesylate (IM) treatment, 400 mg/day orally. Following the IM treatment for a period of 35 mo, the patient underwent partial hepatectomy (S4 + S5). The effect of IM on the metastatic lesions was interpreted as pathologic complete response (CR). Pathologically verified cases showing therapeutic efficacy of IM have been rarely reported.
MeSH terms
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Administration, Oral
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Adult
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / therapeutic use*
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Benzamides
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Chemotherapy, Adjuvant
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Gastrectomy
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Gastrointestinal Stromal Tumors / pathology*
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Gastrointestinal Stromal Tumors / surgery
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Hepatectomy*
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Humans
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Imatinib Mesylate
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Liver Neoplasms / drug therapy*
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Liver Neoplasms / secondary
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Liver Neoplasms / surgery*
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Magnetic Resonance Imaging
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Male
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Neoadjuvant Therapy
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Piperazines / administration & dosage
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Piperazines / therapeutic use*
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Protein Kinase Inhibitors / administration & dosage
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Protein Kinase Inhibitors / therapeutic use*
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Pyrimidines / administration & dosage
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Pyrimidines / therapeutic use*
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Tomography, X-Ray Computed
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Treatment Outcome
Substances
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Antineoplastic Agents
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Benzamides
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Piperazines
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Protein Kinase Inhibitors
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Pyrimidines
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Imatinib Mesylate