Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins

Ajaikumar B Kunnumakkara; Preetha Anand; Bharat B Aggarwal

doi:10.1016/j.canlet.2008.03.009

Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins

Cancer Lett. 2008 Oct 8;269(2):199-225. doi: 10.1016/j.canlet.2008.03.009. Epub 2008 May 13.

Authors

Ajaikumar B Kunnumakkara¹, Preetha Anand, Bharat B Aggarwal

Affiliation

¹ Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.

PMID: 18479807
DOI: 10.1016/j.canlet.2008.03.009

Abstract

Because most cancers are caused by dysregulation of as many as 500 different genes, agents that target multiple gene products are needed for prevention and treatment of cancer. Curcumin, a yellow coloring agent in turmeric, has been shown to interact with a wide variety of proteins and modify their expression and activity. These include inflammatory cytokines and enzymes, transcription factors, and gene products linked with cell survival, proliferation, invasion, and angiogenesis. Curcumin has been found to inhibit the proliferation of various tumor cells in culture, prevents carcinogen-induced cancers in rodents, and inhibits the growth of human tumors in xenotransplant or orthotransplant animal models either alone or in combination with chemotherapeutic agents or radiation. Several phase I and phase II clinical trials indicate that curcumin is quite safe and may exhibit therapeutic efficacy. These aspects of curcumin are discussed further in detail in this review.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Angiogenesis Inhibitors / pharmacology*
Animals
Antineoplastic Agents / pharmacology*
Breast Neoplasms / prevention & control
Cell Proliferation / drug effects
Clinical Trials as Topic
Curcumin / chemistry
Curcumin / pharmacokinetics
Curcumin / pharmacology*
Curcumin / therapeutic use
Gastrointestinal Neoplasms / prevention & control
Humans
Interleukins / antagonists & inhibitors
MAP Kinase Signaling System / drug effects
NF-kappa B / antagonists & inhibitors
Neoplasm Invasiveness
Neoplasm Metastasis / prevention & control
Neoplasms / drug therapy*
PPAR gamma / drug effects
STAT Transcription Factors / antagonists & inhibitors
Signal Transduction / drug effects*
Transcription Factor AP-1 / antagonists & inhibitors
Vascular Endothelial Growth Factor A / antagonists & inhibitors

Substances

Angiogenesis Inhibitors
Antineoplastic Agents
Interleukins
NF-kappa B
PPAR gamma
STAT Transcription Factors
Transcription Factor AP-1
Vascular Endothelial Growth Factor A
Curcumin