Sings of pancreas damage among 206 patients with chronic hepatitis B (CHB) appears in 45.1%: hyperamylasemia--in 18.9% patients, ultrasonography (USG) sings of pancreatic disorders--in 44.2%. Some parallelism was revealed between increasing of frequency and degree of pancreas damage and rising of CHB activity and viremia intensity. Pancreas USG can early revealed the symptoms of pancreas damage. Among all USG pancreas parameters in CHB changes of pancreas sound thickness appears more frequency, pancreas contours, sizes and structure changed more rarely.