Abstract
Sulforaphane (SF) is a phytochemical that displays both anticarcinogenic and anticancer activity. SF modulates many cancer-related events, including susceptibility to carcinogens, cell death, cell cycle, angiogenesis, invasion and metastasis. We review its discovery and development as a cancer chemopreventive agent with the intention of encouraging further research on this important compound and facilitating the identification and development of new phytochemicals for cancer prevention.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Anticarcinogenic Agents / isolation & purification
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Anticarcinogenic Agents / metabolism
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Anticarcinogenic Agents / pharmacology
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Anticarcinogenic Agents / therapeutic use*
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Humans
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Isothiocyanates
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Neoplasms / prevention & control*
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Sulfoxides
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Thiocyanates / isolation & purification
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Thiocyanates / metabolism
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Thiocyanates / pharmacology
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Thiocyanates / therapeutic use*
Substances
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Anticarcinogenic Agents
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Isothiocyanates
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Sulfoxides
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Thiocyanates
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sulforaphane