Structure-activity relationships of novel N-acyloxy-1,4-dihydropyridines as P-glycoprotein inhibitors

Burkhardt Voigt; Claudius Coburger; Joséf Monár; Andreas Hilgeroth

doi:10.1016/j.bmc.2007.05.036

Structure-activity relationships of novel N-acyloxy-1,4-dihydropyridines as P-glycoprotein inhibitors

Bioorg Med Chem. 2007 Aug 1;15(15):5110-3. doi: 10.1016/j.bmc.2007.05.036. Epub 2007 May 18.

Authors

Burkhardt Voigt¹, Claudius Coburger, Joséf Monár, Andreas Hilgeroth

Affiliation

¹ Institute of Pharmacy, Martin Luther University, Halle, Germany.

PMID: 17533131
DOI: 10.1016/j.bmc.2007.05.036

Abstract

Series of novel N-acyloxy-1,4-dihydropyridines have been synthesized and evaluated as P-glycoprotein inhibitors in an in vitro assay to estimate their potential to act as multidrug resistance modulators in cancer cells. Structure-activity relationships are discussed and prove a significant and regiospecific influence of certain functional groups.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors*
Animals
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Dihydropyridines / chemistry*
Dihydropyridines / pharmacology*
Drug Resistance, Neoplasm / drug effects
Lymphoma / drug therapy
Mice
Structure-Activity Relationship

Substances

ATP Binding Cassette Transporter, Subfamily B, Member 1
Antineoplastic Agents
Dihydropyridines