Abstract
Within 24h four cardiac hormones, i.e., vessel dilator, kaliuretic peptide, atrial natriuretic peptide, and long acting natriuretic peptide decrease the number of human glioblastoma cells 75%, 68%, 67%, and 65% while Dendroaspis (green mamba) peptide caused a 17% decrease when each were utilized at 100 microM. The four cardiac hormones decreased DNA synthesis 65-87% and increased cyclic GMP 1.3- to 3.8-fold in the glioblastoma cells. Natriuretic peptide receptors (NPR)-A and -C were present.
Conclusion:
four cardiac hormones eliminate up to 75% of glioblastoma cells via cyclic GMP-mediated up to 87% decrease in DNA synthesis.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology
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Atrial Natriuretic Factor / pharmacology*
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Blotting, Western
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Cell Line, Tumor
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Cell Proliferation / drug effects*
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DNA, Neoplasm / biosynthesis
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Dose-Response Relationship, Drug
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Elapidae / metabolism
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Glioblastoma / genetics
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Glioblastoma / metabolism
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Glioblastoma / pathology
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Humans
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Myocardium / chemistry
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Myocardium / metabolism
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Peptide Fragments / pharmacology
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Peptides / pharmacology*
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Protein Precursors / pharmacology*
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Receptors, Atrial Natriuretic Factor / metabolism
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Time Factors
Substances
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Antineoplastic Agents
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DNA, Neoplasm
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Peptide Fragments
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Peptides
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Protein Precursors
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atrial natriuretic factor precursor (79-98)
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atrial natriuretic factor prohormone (1-30), human
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atrial natriuretic factor prohormone (31-67)
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Atrial Natriuretic Factor
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Receptors, Atrial Natriuretic Factor