Abstract
Fifteen polymethoxyflavones (PMFs) and hydroxylated PMFs were isolated from sweet orange (Citrus sinensis) peel extract and synthesized to investigate their biological activity. All obtained compounds were tested in HL-60 cancer cell proliferation and apoptosis induction assays. While some PMFs and hydroxylated PMFs had moderate anti-carcinogenic activities, 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone showed strong inhibitory activities against the proliferation and induced apoptosis of HL-60 cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anticarcinogenic Agents / chemical synthesis
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Anticarcinogenic Agents / pharmacology
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Antineoplastic Agents, Phytogenic / chemical synthesis*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Apoptosis / drug effects
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Cell Proliferation / drug effects
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Chromatography, High Pressure Liquid
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Citrus / chemistry*
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Flavones / isolation & purification
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Flavones / physiology*
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Fruit / chemistry
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HL-60 Cells
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Humans
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Hydroxylation
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Plant Extracts / chemistry
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Ultraviolet
Substances
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Anticarcinogenic Agents
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Antineoplastic Agents, Phytogenic
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Flavones
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Indicators and Reagents
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Plant Extracts