Initial and long-term outcome after palliative surgical drainage of 269 patients with malignant biliary obstruction

Eur J Surg Oncol. 2007 Aug;33(6):757-62. doi: 10.1016/j.ejso.2006.11.014. Epub 2007 Jan 9.

Abstract

Aims: This study aimed to analyse the current outcome after palliative surgical drainage of malignant biliary obstruction.

Method: From 1992 to 2003, perioperative parameters and the incidence and indications of readmissions were analysed in 269 patients who underwent a palliative biliary bypass for periampullary carcinoma.

Results: Hospital mortality occurred in seven patients and median postoperative stay was 10 days. Anastomotic leakage occurred in three patients and intraabdominal haemorrhage in eight patients. Overall 75 patients experienced a complication. Nine patients underwent a relaparotomy during initial hospital admission. Overall, 142 patients were readmitted, 13 for indications related to the biliary bypass, 11 for surgery-related indications. Twenty-five patients were readmitted for radiochemotherapy, 112 for progressive disease and 23 for indications not related to the disease. Median survival was 7.5 months and the 3-year survival 3%. Survival was significantly lower in patients with metastases and in those who underwent elective bypass for gastric outlet obstruction.

Conclusion: Current hospital mortality after palliative biliary bypass as well as readmission rates for complications related to the biliary bypass or surgical procedure are low. Surgical biliary bypass is a safe and effective palliative treatment for patients with malignant biliary obstruction.

MeSH terms

  • Ampulla of Vater / surgery*
  • Anastomosis, Surgical / adverse effects
  • Carcinoma / complications*
  • Chemotherapy, Adjuvant
  • Cholestasis, Extrahepatic / etiology
  • Cholestasis, Extrahepatic / surgery*
  • Common Bile Duct Diseases / etiology
  • Common Bile Duct Diseases / surgery*
  • Common Bile Duct Neoplasms / complications*
  • Disease Progression
  • Drainage*
  • Female
  • Follow-Up Studies
  • Hospitalization
  • Humans
  • Laparotomy
  • Length of Stay
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Palliative Care*
  • Patient Readmission
  • Postoperative Hemorrhage / etiology
  • Radiotherapy, Adjuvant
  • Reoperation
  • Survival Rate
  • Treatment Outcome