Abstract
Ependymomas are tumours that arise throughout the central nervous system. Little is known regarding the aberrant cellular and molecular processes that generate these tumours. This lack of knowledge has hampered efforts to reduce the significant mortality and morbidity that are associated with ependymoma. Here, we review recent data that suggest that radial glia are cells of origin of ependymoma, and discuss the processes that might transform these neural progenitors into ependymoma cancer stem cells.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Brain Neoplasms / metabolism*
-
Brain Neoplasms / pathology
-
Cell Transformation, Neoplastic
-
Central Nervous System Neoplasms / metabolism*
-
Central Nervous System Neoplasms / pathology
-
Ependymoma / metabolism*
-
Ependymoma / pathology
-
Humans
-
Models, Biological
-
Neoplastic Stem Cells / metabolism*
-
Neoplastic Stem Cells / pathology
-
Neuroglia / metabolism
-
Neuroglia / pathology
-
Signal Transduction