Abstract
We describe here a nontoxic two-photon photodynamic nanoparticle platform and its cellular application. We demonstrate that the dye's potential toxicity can be circumvented by its permanent encapsulation into a biocompatible nanoparticle polymer matrix; this was examined by dye leaching experiments and confirmed by cell uptake experiments. Infrared two-photon nanoplatform phototoxicity was demonstrated for rat C6 glioma cells, while the controls showed no dark toxicity for these living cells.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Animals
-
Cell Line, Tumor
-
Cell Survival / drug effects
-
Cell Survival / radiation effects
-
Drug Screening Assays, Antitumor
-
In Vitro Techniques
-
Nanoparticles / chemistry*
-
Photochemotherapy / methods*
-
Photons
-
Photosensitizing Agents / chemistry
-
Photosensitizing Agents / pharmacology*
-
Photosensitizing Agents / radiation effects
-
Porphyrins / chemistry
-
Porphyrins / pharmacology*
-
Porphyrins / radiation effects
-
Rats
-
Structure-Activity Relationship
-
Xenon
Substances
-
Photosensitizing Agents
-
Porphyrins
-
tetra(4-N-methylpyridyl)porphine
-
Xenon