Abstract
ERK1/2 is an important subfamily of mitogen-activated protein kinases that control a broad range of cellular activities and physiological processes. ERK1/2 can be activated transiently or persistently by MEK1/2 and upstream MAP3Ks in conjunction with regulation and involvement of scaffolding proteins and phosphatases. Activation of ERK1/2 generally promotes cell survival; but under certain conditions, ERK1/2 can have pro-apoptotic functions.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apoptosis / drug effects
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Apoptosis / physiology*
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Cell Survival / physiology
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Extracellular Signal-Regulated MAP Kinases / physiology*
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Humans
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MAP Kinase Kinase 1 / physiology
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MAP Kinase Kinase 2 / physiology
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MAP Kinase Kinase Kinases / physiology
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MAP Kinase Signaling System / physiology*
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Mitogen-Activated Protein Kinase 1 / physiology
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Mitogen-Activated Protein Kinase 3 / physiology
Substances
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Extracellular Signal-Regulated MAP Kinases
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Mitogen-Activated Protein Kinase 1
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Mitogen-Activated Protein Kinase 3
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MAP Kinase Kinase Kinases
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MAP Kinase Kinase 1
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MAP Kinase Kinase 2