Herpes simplex and Epstein-Barr virus lymphadenitis in a patient with chronic lymphocytic leukemia treated with fludarabine

Eur J Haematol. 2006 Nov;77(5):442-4. doi: 10.1111/j.1600-0609.2006.00738.x.

Abstract

Multiple herpes virus co-infection is a very rare complication in patients with chronic lymphocytic leukemia (CLL). We describe a patient with a CLL who developed an herpes virus lymphadenitis. Inmunohistochemical study was positive for HSV-1, HSV-2, and Epstein-Barr Virus (EBV). The coinfection of EBV with a profile of expresion of viral latent genes type III, is usually seen in inmunodepressed patients. To the best of our knowledge, this is the first reported case of a multiple human herpes virus infection mimicking Richter syndrome.

Publication types

  • Case Reports

MeSH terms

  • Acyclovir / administration & dosage
  • Aged
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / adverse effects
  • Antiviral Agents / administration & dosage
  • Female
  • Gene Expression Profiling / methods
  • Gene Expression Regulation, Viral / drug effects
  • Herpesviridae Infections / drug therapy
  • Herpesviridae Infections / etiology
  • Herpesviridae Infections / genetics
  • Herpesviridae Infections / virology*
  • Herpesvirus 1, Human* / genetics
  • Herpesvirus 2, Human* / genetics
  • Herpesvirus 4, Human* / genetics
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / complications
  • Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics
  • Leukemia, Lymphocytic, Chronic, B-Cell / virology
  • Lymphadenitis / drug therapy
  • Lymphadenitis / etiology
  • Lymphadenitis / genetics
  • Lymphadenitis / virology*
  • Vidarabine / administration & dosage
  • Vidarabine / adverse effects
  • Vidarabine / analogs & derivatives*

Substances

  • Antineoplastic Agents
  • Antiviral Agents
  • Vidarabine
  • fludarabine
  • Acyclovir