Abstract
The antiproliferative effects of bistramide A, a nitrogenous dilactam polyether from Lissoclinum bistratum Sluiter (Urochordata), were studied at the level of the cell cycle in asynchronous cells of the NSCLCN6-L16 line. Bistramide A has a dual mechanism that induces blockade in the G1 phase (compatible with differentiation properties reported elsewhere) and causes polyploidy that is suggestive of inaptitude for cytokinesis. These effects confirm the results of cytomorphology studies in electron microscopy.
MeSH terms
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Acetamides*
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Animals
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Antineoplastic Agents / therapeutic use*
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Antineoplastic Agents / toxicity
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Carcinoma, Bronchogenic / drug therapy*
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Carcinoma, Bronchogenic / ultrastructure
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Carcinoma, Non-Small-Cell Lung / drug therapy*
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Carcinoma, Non-Small-Cell Lung / ultrastructure
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Cell Cycle / drug effects
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Cell Line
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Drug Screening Assays, Antitumor
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Ethers, Cyclic / therapeutic use*
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Ethers, Cyclic / toxicity
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Flow Cytometry
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Humans
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Lung Neoplasms / drug therapy*
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Lung Neoplasms / ultrastructure
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Mice
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Mice, Nude
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Microscopy, Electron
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Neoplasm Transplantation
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Pyrans*
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Spiro Compounds
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Tumor Cells, Cultured / drug effects
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Tumor Cells, Cultured / ultrastructure
Substances
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Acetamides
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Antineoplastic Agents
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Ethers, Cyclic
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Pyrans
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Spiro Compounds
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bistratene A