Regulation of transferrin receptor expression and control of cell growth

Pathobiology. 1991;59(1):11-8. doi: 10.1159/000163610.

Abstract

Transferrin receptor expression is vital for the continuous growth of most cells. Although iron plays a key role in modulating transferrin receptor expression, other physiological factors are also capable of affecting receptor expression. In hematopoietic cells, these include interleukin-2, interleukin-6, calcium channels, cyclic nucleotides, phorbol esters and viruses. In this review, we will describe how these agents can alter transferrin receptor expression at the levels of transcription, translation and receptor re-cycling.

Publication types

  • Review

MeSH terms

  • Bucladesine / pharmacology
  • Calcium Channels / drug effects
  • Calcium Channels / physiology
  • Cyclic AMP / pharmacology
  • Diltiazem / pharmacology
  • Gene Expression Regulation / drug effects
  • HTLV-I Infections / genetics
  • Human T-lymphotropic virus 1 / physiology
  • Humans
  • Interleukin-6 / pharmacology
  • Interphase / drug effects
  • Lymphocyte Activation
  • Lymphocytes / metabolism
  • Phorbol Esters / pharmacology
  • Receptors, Interleukin-2 / biosynthesis
  • Receptors, Transferrin / biosynthesis*
  • Receptors, Transferrin / physiology
  • Transferrin / physiology*
  • Tumor Cells, Cultured

Substances

  • Calcium Channels
  • Interleukin-6
  • Phorbol Esters
  • Receptors, Interleukin-2
  • Receptors, Transferrin
  • Transferrin
  • Bucladesine
  • Cyclic AMP
  • Diltiazem