Chronic pancreatic inflammation induced by environmental tobacco smoke inhalation in rats

Am J Gastroenterol. 2006 Jan;101(1):148-59. doi: 10.1111/j.1572-0241.2006.00405.x.

Abstract

Objective: Despite a strong epidemiological association between cigarette smoking and pancreatic diseases, such as pancreatic cancer and chronic pancreatitis, the effects of long-term cigarette smoke inhalation on the pancreas have not been clearly determined. In the present study, we investigated the effect of cigarette smoke inhalation on the pancreas.

Methods: Thirty-six female Sprague Dawley rats were exposed to two different doses of environmental tobacco smoke averaging 100 mg or 160 mg/m3 total suspended particulate matter (TSP) per m3 for 70 min twice a day for 12 wk. The animals were sacrificed and examined for the effects of tobacco smoke exposure on pancreatic morphology and function.

Results: In 58% (7/12) of the animals, exposure to 160 mg/m3 TSP cigarette smoke induced a chronic pancreatic inflammatory process with fibrosis and scarring of pancreatic acinar structures. Animals with fibrotic alterations showed an induction of pancreatic pro-collagen 1 gene expression, and the infiltration of immune cells was accompanied by the expression of the inflammatory mediators MIP-1alpha, IL-1beta, and TGF-beta in 33% (4/12) of the animals. Acinar cell stress was manifested by a significant up-regulation of pancreatitis-associated protein expression (PAP) in smoke-exposed animals (smoke-exposed 6,932 +/- 1,236 vs control 3,608 +/- 305, p < 0.05). Possibly contributing to the morphological damage to the exocrine pancreas, the inhalation of cigarette smoke induced trypsinogen and chymotrypsinogen gene expression and, furthermore, reduced pancreatic enzyme content.

Conclusions: This study provides experimental evidence of morphological pancreatic damage induced by the inhalation of cigarette smoke, which is likely to be mediated by alterations of acinar cell function.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biopsy, Needle
  • Cotinine / analysis
  • Cotinine / metabolism
  • Disease Models, Animal
  • Female
  • Immunohistochemistry
  • Nicotine / analysis
  • Nicotine / metabolism
  • Pancreatic Function Tests
  • Pancreatitis, Chronic / etiology*
  • Pancreatitis, Chronic / pathology*
  • Pancreatitis-Associated Proteins
  • Probability
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley
  • Reference Values
  • Risk Factors
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Tobacco Smoke Pollution / adverse effects*

Substances

  • Pancreatitis-Associated Proteins
  • REG3A protein, human
  • Tobacco Smoke Pollution
  • Nicotine
  • Cotinine