Abstract
The polymerization initiators for resins cured using visible light usually consist of a photosensitizer, primarily camphorquinone (CQ), and a reducing agent, which is often a tertiary amine (DMPT, DMAEMA), while the initiator used for self-curing resins consists of benzoyl peroxide (BPO) and a tertiary amine (DMPT). The genotoxicities of camphorquinone (CQ), benzoyl peroxide (BPO), dimethyl-para-toluidine (DMPT), 2-dimethylamino-ethyl-methacrylate (DMAEMA), and 1-allyl-2-thiourea (ATU) were examined using the bioluminescent bacterial genotoxicity test. 4-Nitroquinoline-N-oxide (4NQO) was prepared for comparison with these chemicals. Acetone solutions of the five polymerization initiators and 4NQO were prepared. Benzoyl peroxide (BPO), dimethyl-para-toluidine (DMPT), and 1-allyl-2-thiourea (ATU) showed significant genotoxic activity at 24 h in the bioluminescent bacterial genotoxicity test, at concentrations of approximately 5 microM, 4 mM, and 1 mM, respectively. 2-Dimethyloamino-ethyl-methacrylate (DMAEMA) did not have genotoxic activity and CQ had questionable genotoxic activity. In comparison, 4NQO had strong genotoxicity, at 4 microM, roughly the same as that of BPO. Therefore, BPO should be used carefully in clinical dentistry.
MeSH terms
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4-Nitroquinoline-1-oxide / chemistry
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4-Nitroquinoline-1-oxide / toxicity
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Acetone / chemistry
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Benzoyl Peroxide / chemistry
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Benzoyl Peroxide / toxicity
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Biocompatible Materials / chemistry
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Biocompatible Materials / toxicity*
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Camphor / analogs & derivatives
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Camphor / chemistry
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Camphor / toxicity
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Composite Resins / toxicity*
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Dental Materials / toxicity*
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Dose-Response Relationship, Drug
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Ethylamines / chemistry
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Ethylamines / toxicity
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In Vitro Techniques
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Inhibitory Concentration 50
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Light
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Methacrylates / chemistry
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Methacrylates / toxicity
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Molecular Structure
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Mutagenicity Tests*
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Photosensitizing Agents / toxicity
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Quinolones / chemistry
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Quinolones / toxicity
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Reducing Agents / chemistry
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Reducing Agents / toxicity
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Solutions / chemistry
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Sulfonium Compounds / toxicity
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Thiourea / analogs & derivatives
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Thiourea / chemistry
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Thiourea / toxicity
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Toluidines / chemistry
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Toluidines / toxicity
Substances
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2-dimethylaminoethyl methacrylate
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4-nitroquinolone-1-oxide
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Biocompatible Materials
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Composite Resins
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Dental Materials
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Ethylamines
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Methacrylates
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Photosensitizing Agents
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Quinolones
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Reducing Agents
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Solutions
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Sulfonium Compounds
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Toluidines
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Acetone
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4-Nitroquinoline-1-oxide
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Camphor
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dimethylpropiothetin
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Thiourea
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dimethyl-4-toluidine
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Benzoyl Peroxide