Abstract
Five new sesquiterpene chromone derivatives, fukanefurochromones A-E (1-5), were isolated from a 80% aqueous methanol extract of the roots of Ferula fukanensis. The structures were elucidated on the basis of spectroscopic evidence, especially heteronuclear multiple-bond connectivity (HMBC) and high-resolution MS. The sesquiterpene chromone derivatives inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chromones / chemistry
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Chromones / isolation & purification*
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Chromones / pharmacology
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology
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Ferula / chemistry*
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Macrophage Activation
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Molecular Structure
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Nitric Oxide / antagonists & inhibitors*
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Nitric Oxide / biosynthesis
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Nitric Oxide / metabolism
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Nitric Oxide Synthase Type II / antagonists & inhibitors*
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Reverse Transcriptase Polymerase Chain Reaction
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
Substances
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Chromones
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Drugs, Chinese Herbal
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Enzyme Inhibitors
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Sesquiterpenes
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Nitric Oxide
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Nitric Oxide Synthase Type II