Abstract
The methanol extract of Cyperus rotundus rhizome, given orally at the doses of 250 and 500 mg/kg b.w., showed significant antidiarrhoeal activity in castor oil induced diarrhoea in mice. Among the fractions, tested at 250 mg/kg, the petroleum ether fraction (PEF) and residual methanol fraction (RMF) were found to retain the activity, the latter being more active as compared to the control. The ethyl acetate fraction (EAF) did not show any antidiarrhoeal activity.
MeSH terms
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Animals
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Antidiarrheals / administration & dosage
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Antidiarrheals / isolation & purification*
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Antidiarrheals / therapeutic use*
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Castor Oil / pharmacology
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Cyperus / chemistry*
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Diarrhea / chemically induced
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Diarrhea / drug therapy*
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Dose-Response Relationship, Drug
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Female
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Male
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Medicine, Traditional
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Methanol / chemistry
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Mice
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / chemistry
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Plant Extracts / therapeutic use*
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Rhizome / chemistry
Substances
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Antidiarrheals
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Plant Extracts
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Castor Oil
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Methanol