Abstract
In the present study, cyclin I protein expression in 114 invasive human breast cancers was correlated with cell cycle and angiogenesis-related proteins and clinico-pathological data. A strong association was found between cytoplasmic cyclin I staining and VEGF (p = 0.001) as well as the VEGF receptor KDR (p = 0.001), suggesting a link between cyclin I and angiogenesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Breast Neoplasms / metabolism*
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Cyclin I
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Cyclins / metabolism*
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Female
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Gene Expression Regulation, Neoplastic
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Humans
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Immunoenzyme Techniques
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Molecular Sequence Data
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Neoplasm Invasiveness*
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Neovascularization, Pathologic / metabolism
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Vascular Endothelial Growth Factor A / metabolism*
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Vascular Endothelial Growth Factor Receptor-2 / metabolism*
Substances
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CCNI protein, human
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Cyclin I
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Cyclins
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factor Receptor-2