3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells

Jonathan R Dimmock; Umashankar Das; H Inci Gul; Masami Kawase; Hiroshi Sakagami; Zoltán Baráth; Imre Ocsovsky; Joseph Molnár

doi:10.1016/j.bmcl.2005.01.054

3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells

Bioorg Med Chem Lett. 2005 Mar 15;15(6):1633-6. doi: 10.1016/j.bmcl.2005.01.054.

Authors

Jonathan R Dimmock¹, Umashankar Das, H Inci Gul, Masami Kawase, Hiroshi Sakagami, Zoltán Baráth, Imre Ocsovsky, Joseph Molnár

Affiliation

¹ College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, SK, Canada S7N 5C9. dimmock@skyway.usask.ca

PMID: 15745812
DOI: 10.1016/j.bmcl.2005.01.054

Abstract

The incorporation of the 1-aryl-5-(4-nitrophenyl)-3-oxo-1,4-pentadienyl group into 3,4-dihydro-1H-naphthalenyl, cyclohexyl, 2,3-dihydro-1H-indenyl and cyclopentyl scaffolds led to the discovery of various compounds with selective toxicity for malignant cells and ability to reverse multidrug resistance.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Colonic Neoplasms / drug therapy
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm / drug effects*
Humans
Ketones / chemical synthesis
Ketones / chemistry*
Ketones / pharmacology*
Leukemia L5178 / drug therapy
Molecular Structure

Substances

Antineoplastic Agents
Ketones